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Pre-clinical data suggests upregulation of nerve growth factor and vascular endothelial growth factor in injury models [9]
In experimental models it is used to explore mechanisms of tissue regeneration, angiogenesis, inflammatory modulation and maintenance of gastrointestinal barrier integrity
While sulfur burps specifically are not explicitly listed in clinical trial data, belching is a recognized side effect that may be more noticeable during initial dose titration when the digestive system is adapting to the medication's effects
PMID 37973897
The exact mechanism by which semaglutide benefits knee OA requires further study, but initial results show great promise: A mean change in knee pain, which was assessed using the WOMAC criteria for pain scoring , demonstrated a reduction of 41.7 points for semaglutide and a decrease of 27.5 points for a matching placebo
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